THE RELATIONSHIP BETWEEN OXIDATIVE STRESS AND NEUROLOGICAL DISORDERS: MINI REVIEW

Received: 20.02.2024/Accepted: 29.03.2024/Published online: 29.04.2024
УДК 616.8-009
DOI: 10.53511/pharmkaz.2024.36.46.010

Z.D. Kulbayeva 1 ,D.A.Klyuyev 2, Sh. S. Kalieva 3, A.A. Muratbek 4
NС JSC “MUK”, Karaganda, Kazakhstan

THE RELATIONSHIP BETWEEN OXIDATIVE STRESS AND NEUROLOGICAL DISORDERS: MINI REVIEW
Resume: Oxidative stress is one of the main causes of neuronal dysfunction and death, mainly due to excessive formation of
reactive oxygen species and depletion of antioxidant reserves. Oxidative stress is characterized by an imbalance between the
production of reactive oxygen species (ROS) and antioxidant defense mechanisms of the body. This process is involved in the
onset and development of many neurological diseases. In this review, we analyzed and summarized the results of studies
showing the association of neurological diseases, such as stroke, Parkinson’s disease, and other neurological diseases, with
excessive formation of oxidative stress products. This article aims to provide an overview of the relationship between
oxidative stress and a range of neurological conditions, shedding light on the underlying mechanisms and potential
therapeutic implications.
Keywords: oxidative stress, reactive oxygen species, neurodegenerative diseases, stroke, Parkinson’s disease, Alzheimer’s
disease, Huntington’s disease, multiple sclerosis.

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