Received: 19/08/2023/ Accepted: 27/09/2023 / Published online: October 30, 2023
UDC 76.31.33
DOI 10.53511/PHARMKAZ.2023.62.80.050
1A.A. MANASSOVA*, 1A.ZH. ZHOLDASBAУ, 1K.A.ZHAPARKULOVA, 1F.A. OTAROVA, 1T.S. BEKEZHANOVA, 1A.S. KELEKE
1 Asfendiyarov Kazakh National Medical University, Kazakhstan, Almaty
* Corresponding author – A.A. Manassova, akhmetche@gmail.com, Department of Biotechnology and General Chemical
Technology, Asfendiyarov Kazakh National Medical University, Kazakhstan, Almaty 050012, 94 Tole bi Street
DISTRIBUTION AND USE IN FOLK MEDICINE OF PLANTS OF THE GENUS
YARROW (ACHILLEA L.)
Resume: This article presents an overview of the use in folk medicine of yarrow (Achillea L.) genus plants. The
purpose of the review is to systematize and summarize the existing scientific data on the ethnopharmaceutical
use and distribution of yarrow species.
Yarrow is a genus of herbaceous plants known for its medicinal properties and wide use in folk and contemporary
medicine. The genus Achillea, one of the most famous genera of this Asteraceae family, has about 150 species
growing throughout the northern hemisphere, 14 species of which are found on the territory of Kazakhstan.
The data being reviewed show a wide range of uses for Achillea plants ranging from central nervous system
diseases to gastrointestinal disorders. It is noted that only three Kazakh species of yarrow are known to be
used in folk medicine: A. filipendulina, A. millefolium, A. nobilis. At the same time, only A. filipendulina has found
application in local folk practice as a remedy for gastrointestinal diseases and as an abortive agent. According
to this observation, it was accepted that the species of A. filipendulina is of significant scientific and practical
interest as an object of research.
Keywords: Achillea, Achillea filipendulina, traditional medicine, biological activity, review.
REFERENCES
1 WHO Traditional Medicine Strategy 2014-2023 WHO, 2014.- 75 p.
2 Panesh Olga Askarbievna, Chitao Svetlana Ilyasovna, Chernyavskaya Irina Vladimirovna Physiobiological features of local and introduced species of yarrow
in the botanical garden of the Adyghe State University // Bulletin of the Adyghe State University. Series 4: Natural-mathematical and technical sciences. 2020.
No. 4 (271). URL:https://cyberleninka.ru/article/n/fiziobiologicheskie-osobennosti-mestnogo-i-introdutsirovannogo-vidov-tysyachelistnika-v-botanicheskomsadu-adygeyskogo (дата обращения: 21.02.2023).
3 Gryaznov, M. Yu. The first domestic variety of Achillea filipendulina Lam. Zlatoslav / M. Yu. Gryaznov, S. A. Totskaya, O. M. Savchenko // 90 years – from
a plant to a drug: achievements and prospects: Collection of materials of the anniversary international scientific conference, Moscow, June 10–11, 2021. –
Moscow: Federal State Budgetary Scientific Institution “All-Russian Scientific Research Institute of Medicinal and Aromatic Plants”, 2021. – С. 51-55. – DOI
10.52101/9785870191003_2021_51. – EDN VXUNUS.
4 Kupriyanov A.N., Kulemin Yu.E. 2021. Achillea tianschanica Kupr. et Kulemin – a new species from Western Tien Shan and Syrdarya Karatau, Kazakhstan.
Sistematicheskie zametki po materialam Gerbariya im. P.N. Krylova Tomskogo gosudarstvennogo universiteta [Systematic notes on the materials of P.N. Krylov
Herbarium of Tomsk State University], 123: 3–12. https://doi.org/10.17223/20764103.123.1 .(ссылка Kupriyanov A.N)
5 Tzvelev N.N. Achillea L. In: Flora evropejskoj chasti SSSR [Flora of the European part of the USSR]. St. Petersburg: Nauka. 7: 117–127. [In Russian]..
(ссылка Tzvelev N.N)
6 Huber-Morath A. 1974. Die türkischen Arten der Gattung Achillea L. Berlin. 84(2): 123–172.(ссылкаHuber-Morath)
7 Kupriyanov A.N., Kulemin Yu.E. 2020. Genus Achillea L. in the flora of Kazakhstan. Problemy botaniki Yuzhnoi Sibiri i Mongolii [Problems of botany in
Southern Siberia and Mongolia], 19(1): 39–43. [In Russian]. URL: http://journal.asu.ru/bpssm/article/view/pbssm.2020008. (ссылка Kupriyanov A.N. Kulemin
Yu.E)
8 V. P. Kurchenko, N. V. Sushinskaya, A. S. Chubarova [et al.] Biologically active substances of various types of yarrow (Achillea) of the native flora of Belarus
and Kazakhstan /// Ecobiotech 2019: Proceedings of the VI All-Russian Conference with international participation, Ufa, 01–04 October 2019. – Ufa: Ufa Institute
of Biology, 2019. – P. 218-221. – EDN REPKBN. (reference V.P. Kurchenko)
9 El Bouzidi, L., Abbad, A., Hassani, L., Fattarsi, K., Leach, D., Markouk, M., Legendre, L., Bekkouche, K., 2012. Essential oil composition and antimicrobial
activity of wild and cultivated Moroccan Achillea ageratum L.: a rare and threatened medicinal species. Chem. Biodivers. 9 (3), 598–605.
10 Baser, K.H.C., Honda, G., Miki, W., 1986. Herb Drugs and Herbalists in Turkey. Institute for the Study of Languages and Cultures of Asia and Africa, Tokyo
University of Foreign Studies, Tokyo, Japan. Turkoglu, I., Turkoglu, S., Celik, S., Kahyaoglu, M., 2010. Antioxidant and antimicrobial activities of Turkish endemic
Achillea species. Afr. J. Microbiol. Res. 4 (19), 2034–2042.
11 Cakilcioglu, U., Khatun, S., Turkoglu, I., Hayta, S., 2011. Ethnopharmacological survey of medicinal plants in Maden (Elazig-Turkey). J. Ethnopharmacol.
137 (1), 469–486.
12 Zhang, Q., Lu, Z., Ren, T., Ge, Y., Zheng, Y., Yao, D., He, X., Gu, Y., Shi, Q., Huo, C., 2014. Chemical composition of Achillea alpina. Chem. Nat. Compd.
50 (3), 534–536.
13 Ristic, M., Sokovic, M., Grubisic, D., Kovacevic, N., 2004. Chemical analysis and antifungal activity of the essential oil of Achillea atrata L. J. Essent. Oil
Res. 16 (1), 75–78
14 Baytop, T., 1994. A Dictionary of Vernacular Names of Wild Plants of Turkey. Publication of the Turkish Language Society, Ankara, Turkey. Sezik, E., Yeşilada,
E., Honda, G., Takaishi, Y., Takeda, Y., Tanaka, T., 2001. Traditional medicine in Turkey X. Folk medicine in central Anatolia. J. Ethnopharmacol. 75 (2), 95–115.
15 Polatoglu, K., Karakoc, O.C., Goren, N., 2013. Phytotoxic, DPPH scavenging, insecticidal activities and essential oil composition of Achillea vermicularis,
A. teretifolia and proposed chemotypes of A. biebersteinii (Asteraceae). Ind. Crop Prod. 51, 35–45.
16 Alkofahi, A., Batshoun, R., Owais, W., Najib, N., 1996. Biological activity of some Jordanian medicinal plant extracts. Fitoterapia 67 (5), 435–442.
17 Ghorbani, A., 2005. Studies on pharmaceutical ethnobotany in the region of Turkmen Sahra, north of Iran: (part 1): general results. J. Ethnopharmacol.
102 (1), 58–68.
18 Jarić, S., MačUkanović-Jocić, M., Djurdjević, L., Mitrović, M., Kostić, O., Karadžić, B., Pavlović, P., 2015. An ethnobotanical survey of traditionally used plants
on Suva planina mountain (south-eastern Serbia). J. Ethnopharmacol. 175, 93–108.
19 Cornara, L., La Rocca, A., Terrizzano, L., Dente, F., Mariotti, M.G., 2014. Ethnobotanical and phytomedical knowledge in the North-Western Ligurian Alps.
J. Ethnopharmacol. 155 (1), 463–484.
20 Jianu, C., Misca, C., Muntean, S.G., Gruia, A.T., 2015. Composition, antioxidant and antimicrobial activity of the essential oil of Achillea collina Becker
growing wild in western Romania. Hem. Ind. 69 (4), 381–386.
21 Cornara, L., La Rocca, A., Terrizzano, L., Dente, F., Mariotti, M.G., 2014. Ethnobotanical and phytomedical knowledge in the North-Western Ligurian Alps.
J. Ethnopharmacol. 155 (1), 463–484.
22 Sadyrbekov, D.T., Suleimenov, E.M., Tikhonova, E.V., Atazhanova, G.A., Tkachev, A.V., Adekenov, S.M., 2006. Component composition of essential oils
from four species of the genus Achillea growing in Kazakhstan. Chem. Nat. Compd. 42 (3), 294–297.
23 Barel, S., Segal, R., Yashphe, J., 1991. The antimicrobial activity of the essential oil from Achillea fragrantissima. J. Ethnopharmacol. 33 (1–2), 187–191.
24 El-Shazly, A.M., Hafez, S.S., Wink, M., 2004. Comparative study of the essential oils and extracts of Achillea fragrantissima (Forssk.) Sch Bip. and Achillea
santolina L. (Asteraceae) from Egypt. Pharmazie 59 (3), 226–230.
25 Boulos, L., 1983. Medicinal Plants of North Africa. Reference Publication, Inc, Agonac Michigen. Eissa, T.A.F., Palomino, O.M., Carretero, M.E., GómezSerranillos, M.P., 2014. Ethnopharmacological study of medicinal plants used in the treatment of CNS disorders in Sinai Peninsula, Egypt. J. Ethnopharmacol.
151 (1), 317–332.
26 Abdel-Rahman, R.F., Alqasoumi, S.I., El-Desoky, A.H., Soliman, G.A., Pare, P.W., Hegazy, M.E.F., 2015. Evaluation of the anti-inflammatory, analgesic an
antiulcerogenic potentials of Achillea fragrantissima (Forssk.). South Afr. J. Bot. 98, 122–127.
27 Bruni, A., Ballero, M., Poli, F., 1997. Quantitative ethnopharmacological study of the Campidano Valley and Urzulei district, Sardinia, Italy. J. Ethnopharmacol.
57 (2), 97–124.
28 Viegi, L., Pieroni, A., Guarrera, P.M., Vangelisti, R., 2003. A review of plants used in folk veterinary medicine in Italy as basis for a databank. J.
Ethnopharmacol. 89 (2), 221–244.
29 Bader, A., Panizzi, L., Cioni, P.L., Flamini, G., 2007. Achillea ligustica: composition and antimicrobial activity of essential oils from the leaves, flowers and
some pure constituents. Cent. Eur. J. Biol. 2 (2), 206–212.
30 Muselli, A., Pau, M., Desjobert, J.-M., Foddai, M., Usai, M., Costa, J., 2009. Volatile constituents of Achillea ligustica All. by HS-SPME/GC/GC-MS.
Comparison with essential oils obtained by hydrodistillation from Corsica and Sardinia. Chromatographia 69 (5–6), 575–585.
31 Agnihotri, V.K., Lattoo, S.K., Thappa, R.K., Kaul, P., Qazi, G.N., Dhar, A.K., Saraf, A., Kapahi, B.K., Saxena, R.K., Agarwal, S.G., 2005. Chemical variability
in the essential oil components of Achillea millefolium Agg. from different Himalayan habitats (India). Planta Med. 71 (3), 280–283.
32 Lin, L.T., Liu, L.T., Chiang, L.C., Lin, C.C., 2002. In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother. Res. 16 (5), 440–444.
33 Cavalcanti, A.M., Baggio, C.H., Freitas, C.S., Rieck, L., de Sousa, R.S., Da Silva-Santos, J.E., Mesia-Vela, S., Andrade Marques, M.C., 2006. Safety and
antiulcer efficacy studies of Achillea millefolium L. after chronic treatment in Wistar rats. J. Ethnopharmacol. 107 (2), 277–284.
34 Benedek, B., Rothwangl-Wiltschnigg, K., Rozeivia, E., Gioncaj, N., Reznicek, G., Jurenitsch, J., Kopp, B., Glasl, S., 2008. Yarrow (Achillea millefolium L.
s.I.): pharmaceutical quality of commercial samples. Pharmazie 63 (1), 23–26.
35 Chou, S.-T., Peng, H.-Y., Hsu, J.-C., Lin, C.-C., Shih, Y., 2013. Achillea millefolium L. essential oil inhibits LPS-induced oxidative stress and nitric oxide
production in RAW 264.7 macrophages. Int. J. Mol. Sci. 14 (7), 12978–12993.
36 Vladic, J., Ambrus, R., Szabo-Revesz, P., Vasic, A., Cvejin, A., Pavlic, B., Vidovic, S. 2016. Recycling of filter tea industry by-products: production of A.
millefolium powder using spray drying technique. Ind. Crop Prod. 80, 197–206.
37 Baytop, T., 1994. A Dictionary of Vernacular Names of Wild Plants of Turkey. Publication of the Turkish Language Society, Ankara, Turkey.
38 Cornara, L., La Rocca, A., Terrizzano, L., Dente, F., Mariotti, M.G., 2014. Ethnobotanical and phytomedical knowledge in the North-Western Ligurian Alps.
J. Ethnopharmacol. 155 (1), 463–484.
39 Anonymous, 1985. The Wealth of India: A Dictionary of Indian Raw Materials & Industrial Products. Publications & Information Directorate, Council of
Scientific & Industrial Research, India. Shawl, A.S., Srivastava, S.K., Syamasundar, K.V., Tripathi, S., Raina, V.K., 2002. Essential oil composition of Achillea
millefolium L. growing wild in Kashmir, India. Flav. Fragr. J. 17 (3), 165–168.
40 Rao, P.K., Hasan, S.S., Bhellum, B.L., Manhas, R.K., 2015. Ethnomedicinal plants of Kathua district, J & K, India. J. Ethnopharmacol. 171 (1), 12–27.
41 Chatzopoulou, P., Katsiotis, S.T., Svendsen, A.B., 1992. An ascaridole containing essential oil of the Achillea millefolium L. complex growing wild in northern
Greece. J. Essent. Oil Res. 4 (5), 457–459.
42 Shariat-Samsam, H., 1992. Qualitative and Quantitative Evaluation of the Active Constituents and Control Methods for Medicinal Plants. Mani Press, Isfahan,
Iran. Mozaffarian, V., 1996. A Dictionary of Iranian Plant Names. Farhang Moaser Press, Iran. Zargari, A., 1996. Medicinal Plants Tehran University. Publication,
Tehran, Iran. Ardestani, A., Yazdanparast, R., 2007. Antioxidant and free radical scavenging potential of Achillea santolina extracts. Food Chem. 104 (1), 21–29.
43 Omidbaigi, R., 2012. Production and Processing of Medicinal Plants 6th ed.. Behnashr, Astan Ghods Razavi Press, Tehran, Iran.
44 Said, H.M., 1982. Diseases of the Liver: Greco-Arab Concepts. Hamdard Foundation Press, Karachi, Pakistan. Yaeesh, S., Jamal, Q., Khan, A.-u., Gilani,
A.H., 2006. Studie on hepatoprotective, antispasmodic and calcium antagonist activities of the aqueous-methanol extract of Achillea millefolium. Phytother.
Res 20 (7), 546–551.
45 Cavalcanti, A.M., Baggio, C.H., Freitas, C.S., Rieck, L., de Sousa, R.S., Da Silva-Santos, J.E., Mesia-Vela, S., Andrade Marques, M.C., 2006. Safety and
antiulcer efficacy studies of Achillea millefolium L. after chronic treatment in Wistar rats. J. Ethnopharmacol. 107 (2), 277–284.
46 Jarić, S., MačUkanović-Jocić, M., Djurdjević, L., Mitrović, M., Kostić, O., Karadžić, B., Pavlović, P., 2015. An ethnobotanical survey of traditionally used
plants on Suva planina mountain (south-eastern Serbia). J. Ethnopharmacol. 175, 93–108.
47 Martkoplishvili, I., Kvavadze, E., 2015. Some popular medicinal plants and diseases of the Upper Palaeolithic in Western Georgia. J. Ethnopharmacol.
166, 42–52.
48 Dei Cas, L., Pugni, F., Fico, G., 2015. Tradition of use on medicinal species in Valfurva (Sondrio, Italy). J. Ethnopharmacol. 163, 113–134.
49 Polat, R., Cakilcioglu, U., Kaltalioğlu, K., Ulusan, M.D., Türkmen, Z., 2015. An ethnobotanical study on medicinal plants in Espiye and its surrounding
(Giresun- Turkey). J. Ethnopharmacol. 163, 1–11.
50 Ghorbani, A., 2005. Studies on pharmaceutical ethnobotany in the region of Turkmen Sahra, north of Iran: (part 1): general results. J. Ethnopharmacol.
102 (1), 58–68.
51 Alkofahi, A., Batshoun, R., Owais, W., Najib, N., 1996. Biological activity of some Jordanian medicinal plant extracts. Fitoterapia 67 (5), 435–442.
52 Al-douri, N.A., 2000. A survey of medicinal plants and their traditional uses in Iraq. Pharm. Biol. 38 (1), 74–79.
53 Al-Qura’n, S., 2009. Ethnopharmacological survey of wild medicinal plants in Showbak, Jordan. J. Ethnopharmacol. 123 (1), 45–50.
54 Eissa, T.A.F., Palomino, O.M., Carretero, M.E., Gómez-Serranillos, M.P., 2014. Ethnopharmacological study of medicinal plants used in the treatment of
CNS disorders in Sinai Peninsula, Egypt. J. Ethnopharmacol. 151 (1), 317–332.
55 Boulos, L., 1983. Medicinal Plants of North Africa. Reference Publication, Inc, Agonac Michigen.
56 Afsharypuor, S., Asgary, S., Lockwood, G.B., 1996. Constituents of the essential oil of Achillea wilhelmsii from Iran. Planta Med. 62 (1), 77–78.
57 Ahmad, M., Khan, M.P.Z., Mukhtar, A., Zafar, M., Sultana, S., Jahan, S., 2016. Ethnopharmacological survey on medicinal plants used in herbal drinks
among the traditional communities of Pakistan. J. Ethnopharmacol. 184, 154–186.
58 Turkoglu, I., Turkoglu, S., Celik, S., Kahyaoglu, M., 2010. Antioxidant and antimicrobial activities of Turkish endemic Achillea species. Afr. J. Microbiol. Res.
4 (19), 2034–204
59 Rezaeipoor, R., Saeidnia, S., Kamalinejad, M., 1999. Immunosuppressive activity of Achillea talagonica on humoral immune responses in experimental
animals. J. Ethnopharmacol. 65 (3), 273–276.
60 Al-Qura’n, S., 2009. Ethnopharmacological survey of wild medicinal plants in Showbak, Jordan. J. Ethnopharmacol. 123 (1), 45–50.
61 Mükemre, M., Behçet, L., Çakılcıoğlu, U., 2015. Ethnobotanical study on medicinal plants in villages of Çatak (Van-Turkey). J. Ethnopharmacol. 166, 361–
374.
62 Asgary, S., Naderi, G.H., Sarrafzadegan, N., Mohammadifard, N., Mostafavi, S., Vakili, R., 2000. Antihypertensive and antihyperlipidemic effects of Achillea
wilhelmsii. Drug Exp. Clin. Res. 26 (3), 89–93.
63 Maffei, M., Chialva, F., Codignola, A., 1989. Essential oils and chromosome numbers from Italian Achillea species. J. Essent. Oil Res. 1 (2), 57–64.
64 Cakilcioglu, U., Khatun, S., Turkoglu, I., Hayta, S., 2011. Ethnopharmacological survey of medicinal plants in Maden (Elazig-Turkey). J. Ethnopharmacol.
137 (1), 469–486.
65 Bibi, T., Ahmad, M., Tareen, R.B., Tareen, N.M., Jabeen, R., Rehman, S.-U., Sultana, S., Zafar, M., Yaseen, G., 2014. Ethnobotany of medicinal plants in
district Mastung of Balochistan province-Pakistan. J. Ethnopharmacol. 157, 79–89.
66 Xie, Z.W., Yu, Y.Q., 1996. A Compendium of Traditional Chinese Medicinal Herbs. I. People’s Medical Publishing House, China. Yang, M., Li, J.X., Li, X.,
Jia, Z.J., 2005. Sesquiterpenes and other constituents from Achillea wilsoniana. Pharmazie 60 (7), 554–558.
67 Behvar A., Sudabeh M., Gokhan Z., Leila D., Mir Barak B. “In-depth study of phytochemical composition antioxidant activity, enzyme inhibitory and
antiproliferative properties of Achillea filipendulina L.: a good candidate for designing biologically active food products”, 2020
68 D. T. Sadyrbekov, E. M. Suleimenov, E. V. Tikhonova, G. A. Atazhanova, A. V. Tkachev, and S. M. Adekenov “Component composition of essential oils from
four species of the genus achillea growing in kazakhstan”, 2006