ПОРАЖЕНИЯ КОЖИ У ПАЦИЕНТОВ С SARS-COV-2-АССОЦИИРОВАННОЙ ПАТОЛОГИЕЙ

DOI 10.53511/PHARMKAZ.2023.79.43.005

А.Д. Кабирова1, А.М. Курманова1, А.Ю. Акпарова1
1Казахский Национальный Университет имени Аль-Фараби, Алматы, Казахстан

ПОРАЖЕНИЯ КОЖИ У ПАЦИЕНТОВ
С SARS-COV-2-АССОЦИИРОВАННОЙ ПАТОЛОГИЕЙ

Резюме: Вспышка тяжелого острого респираторного синдрома, вызванного вирусом, принадлежащим к роду бета-коронавирусов, впервые возникла в китайском городе Ухань в декабре 2019 года.
Возбудитель – одноцепочечный РНК-вирус семейства Coronaviridae. Этот вирус имеет более чем
80% сходство с ранее зарегистрированным в 2003 году SARS-CoV, и, в связи с этим, Международный комитет по таксономии вирусов (ICTV) присвоил ему название SARS-CoV-2, а ВОЗ дала название заболеванию COVID-19 (COrona VIrus Disease 2019).
Заражение вирусом происходит преимущественно при его попадании на слизистые верхних дыхательных путей. Поражаться может не только респираторная система, но и сердечно-сосудистая система, желудочно-кишечный тракт, свертывающая система крови, нервная система, кожа.
В данном обзоре литературы предпринята попытка обобщить имеющуюся информацию о кожных проявлениях COVID-19 с освещением сведений о вариантах кожного васкулита у пациентов с
SARS-CoV-2-ассоциированной патологией.
Поиск литературы был осуществлен в электронных базах MEDLINE, PubMed, EMBASE, Web of
Science, Google Scholar и e-library, по ключевым словосочетаниям: кожные проявления и COVID-19,
кожный васкулит и COVID-19, кожный васкулит и вакцинация против COVID-19. Глубина поиска составила 3 года (с 2020 года по 2022). Релевантные с темой работы были рассмотрены для включения в обзор.
Ключевые слова: COVID-19, SARS-CoV-2, кожные проявления, кожный васкулит, вакцинация против COVID-19.

СПИСОК ЛИТЕРАТУРЫ
1 Guan W jie, Ni Z yi, Hu Y, Liang W hua, Ou C quan, He J xing, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal of
Medicine. 2020;382(18). doi: 10.1056/NEJMoa2002032
2 Chilamakuri R, Agarwal S. Covid-19: Characteristics and therapeutics. Cells. 2021;10(2). doi: 10.3390/cells10020206
3 Li G, Fan Y, Lai Y, Han T, Li Z, Zhou P, et al. Coronavirus infections and immune responses. Vol. 92, Journal of Medical Virology. 2020. doi: 10.1002/jmv.25685
4 Novak N, Peng W, Naegeli MC, Galvan C, Kolm-Djamei I, Brüggen C, et al. SARS-CoV-2, COVID-19, skin and immunology – What do we know so far? Vol.
76, Allergy: European Journal of Allergy and Clinical Immunology. 2021. doi: 10.1111/all.14498
5 Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked
by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2). doi: 10.1016/j.cell.2020.02.052
6 Bourgonje AR, Abdulle AE, Timens W, Hillebrands JL, Navis GJ, Gordijn SJ, et al. Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the
pathophysiology of coronavirus disease 2019 (COVID-19). Vol. 251, Journal of Pathology. 2020. doi: 10.1002/path.5471
7 Ionescu MA. COVID-19 skin lesions are rarely positive at RT-PCR test: the macrophage activation with vascular impact and SARS-CoV-2-induced cytokine
storm. Int J Dermatol. 2022;61(1). doi: 10.1111/ijd.15749
8 Gawaz A, Guenova E. Microvascular Skin Manifestations Caused by COVID-19. Vol. 41, Hamostaseologie. 2021. : doi 10.1055/a-1581-6899
9 Magro C, Crowson AN, Franks L, Schaffer PR, Whelan P, Nuovo G. The histologic and molecular correlates of COVID-19 vaccine-induced changes in the
skin. Clin Dermatol. 2021;39(6). doi: 10.1016/j.clindermatol.2021.07.011
10 Freeman EE, McMahon DE, Fitzgerald ME, Fox LP, Rosenbach M, Takeshita J, et al. The American Academy of Dermatology COVID-19 registry:
Crowdsourcing dermatology in the age of COVID-19. J Am Acad Dermatol. 2020;83(2). doi: 10.1016/j.jaad.2020.04.045
11 Recalcati S. Cutaneous manifestations in COVID-19: a first perspective. Vol. 34, Journal of the European Academy of Dermatology and Venereology. 2020.
doi: 10.1111/jdv.16387
12 Hedou M, Carsuzaa F, Chary E, Hainaut E, Cazenave-Roblot F, Masson Regnault M. Comment on ‘Cutaneous manifestations in COVID-19: a first
perspective’ by Recalcati S. Vol. 34, Journal of the European Academy of Dermatology and Venereology. 2020. doi: 10.1111/jdv.16519
13 Gottlieb M, Long B. Dermatologic manifestations and complications of COVID-19. American Journal of Emergency Medicine. 2020;38(9). doi: 10.1016/j.
ajem.2020.06.011
14 Magro C, Mulvey JJ, Berlin D, Nuovo G, Salvatore S, Harp J, et al. Complement associated microvascular injury and thrombosis in the pathogenesis of
severe COVID-19 infection: A report of five cases. Translational Research. 2020;220. doi: 10.1016/j.trsl.2020.04.007
15 Gianotti R, Veraldi S, Recalcati S, Cusini M, Ghislanzoni M, Boggio F, et al. Cutaneous clinico-pathological findings in three covid-19-positive patients
observed in the metropolitan area of Milan, Italy. Vol. 100, Acta Dermato-Venereologica. 2020. doi: 10.2340/00015555-3490
16 Galván Casas C, Català A, Carretero Hernández G, Rodríguez-Jiménez P, Fernández-Nieto D, Rodríguez-Villa Lario A, et al. Classification of the cutaneous
manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases. British Journal of Dermatology. 2020;183(1). doi:
10.1111/bjd.19163
17 Marzano A v., Cassano N, Genovese G, Moltrasio C, Vena GA. Cutaneous manifestations in patients with COVID-19: a preliminary review of an emerging
issue. Vol. 183, British Journal of Dermatology. 2020. doi: 10.1111/bjd.19264
18 Sunderkötter CH, Zelger B, Chen KR, Requena L, Piette W, Carlson JA, et al. Nomenclature of Cutaneous Vasculitis: Dermatologic Addendum to the
2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis and Rheumatology. 2018;70(2). doi: 10.1002/art.40375
19 Carlson JA. The histological assessment of cutaneous vasculitis. Vol. 56, Histopathology. 2010. doi: 10.1111/j.1365-2559.2009.03443.x
20 Levi M, Thachil J, Iba T, Levy JH. Coagulation abnormalities and thrombosis in patients with COVID-19. Vol. 7, The Lancet Haematology. 2020. doi: 10.1016/
S2352-3026(20)30145-9
21 Magro CM, Mulvey J, Kubiak J, Mikhail S, Suster D, Crowson AN, et al. Severe COVID-19: A multifaceted viral vasculopathy syndrome. Ann Diagn Pathol.
2021;50. doi: 10.1016/j.anndiagpath.2020.151645
22 Perna A, Passiatore M, Massaro A, Terrinoni A, Bianchi L, Cilli V, et al. Skin manifestations in COVID-19 patients, state of the art. A systematic review. Vol.
60, International Journal of Dermatology. 2021. doi: 10.1111/ijd.15414
23 Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020; doi: 10.1056/
NEJMoa2002032
24 Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective
cohort study. The Lancet. 2020;395(10229). doi: 10.1016/S0140-6736(20)30566-3
25 Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. Journal
of Thrombosis and Haemostasis. 2020;18(4). doi: 10.1111/jth.14768
26 Zhang L, Yan X, Fan Q, Liu H, Liu X, Liu Z, et al. D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. Journal of Thrombosis
and Haemostasis. 2020;18(6). doi: 10.1111/jth.14859
27 McGonagle D, Bridgewood C, Ramanan A v., Meaney JFM, Watad A. COVID-19 vasculitis and novel vasculitis mimics. Vol. 3, The Lancet Rheumatology.
2021. doi: 10.1016/S2665-9913(20)30420-3
28 Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 Infection in Children. New England Journal of Medicine. 2020;382(17). doi: 10.1056/
NEJMc2005073
29 Gkoutzourelas A, Bogdanos DP, Sakkas LI. Kawasaki Disease and COVID-19. Mediterr J Rheumatol. 2020;31(3 Supplement 2). doi: 10.31138/mjr.31.3.268
30 de Perosanz-Lobo D, Fernandez-Nieto D, Burgos-Blasco P, Selda-Enriquez G, Carretero I, Moreno C, et al. Urticarial vasculitis in COVID-19 infection: a
vasculopathy-related symptom? Vol. 34, Journal of the European Academy of Dermatology and Venereology. 2020. doi: 10.1111/jdv.16713
31 Larson V, Seidenberg R, Caplan A, Brinster NK, Meehan SA, Kim RH. Clinical and histopathological spectrum of delayed adverse cutaneous reactions
following COVID-19 vaccination. J Cutan Pathol. 2022;49(1). doi: 10.1111/cup.14104
32 Gu SL, Jorizzo JL. Urticarial vasculitis. Int J Womens Dermatol. 2021 Jun;7(3):290–7. doi: 10.1016/j.ijwd.2021.01.021
33 Farooq H, Aemaz Ur Rehman M, Asmar A, Asif S, Mushtaq A, Qureshi MA. The pathogenesis of COVID-19-induced IgA nephropathy and IgA vasculitis: A
systematic review. Vol. 17, Journal of Taibah University Medical Sciences. 2022. doi: 10.1016/j.jtumed.2021.08.012
34 Allez M, Denis B, Bouaziz JD, Battistella M, Zagdanski AM, Bayart J, et al. COVID-19–Related IgA Vasculitis. Vol. 72, Arthritis and Rheumatology. 2020.
doi: 10.1002/art.41428
35 Suso AS, Mon C, Oñate Alonso I, Galindo Romo K, Juarez RC, Ramírez CL, et al. IgA Vasculitis With Nephritis (Henoch−Schönlein Purpura) in a COVID-19
Patient. Kidney Int Rep. 2020 Nov;5(11):2074–8. doi: 10.1016/j.ekir.2020.08.016
36 Hoskins B, Keeven N, Dang M, Keller E, Nagpal R. A child with covid-19 and immunoglobulin a vasculitis. Pediatr Ann. 2021;50(1). doi: 10.3928/19382359-
20201211-01
37 Alghoozi DA, Alkhayyat HM. A child with Henoch-Schonlein purpura secondary to a COVID-19 infection. BMJ Case Rep. 2021;14(1). doi: 10.1136/bcr2020-239910
38 Li NL, Papini AB, Shao T, Girard L. Immunoglobulin-A Vasculitis With Renal Involvement in a Patient With COVID-19: A Case Report and Review of Acute
Kidney Injury Related to SARS-CoV-2. Can J Kidney Health Dis. 2021;8. doi: 10.1177/2054358121991684
39 Jacobi M, Lancrei HM, Brosh-Nissimov T, Yeshayahu Y. Purpurona: A Novel Report of COVID-19-Related Henoch-Schonlein Purpura in a Child. Pediatric
Infectious Disease Journal. 2021; doi: 10.1097/INF.0000000000003001
40 Huang Y, Li XJ, Li YQ, Dai W, Shao T, Liu WY, et al. Clinical and pathological findings of SARS-CoV-2 infection and concurrent IgA nephropathy: a case
report. BMC Nephrol. 2020;21(1). doi: 10.1186/s12882-020-02163-3
41 Gurzu S, Satala CB, Melit LE, Streinu-Cercel A, Otelea D, Capalna B, et al. COVID-19 Like Findings in a Fatal Case of Idiopathic Desquamative Interstitial
Pneumonia Associated With IgA Glomerulonephritis in a 13-Month-Old Child. Front Pediatr. 2020;8. doi: 10.3389/fped.2020.586666
42 Sandhu S, Chand S, Bhatnagar A, Dabas R, Bhat S, Kumar H, et al. Possible association between IgA vasculitis and COVID-19. Vol. 34, Dermatologic
Therapy. 2021. doi: 10.1111/dth.14551
43 Barbetta L, Filocamo G, Passoni E, Boggio F, Folli C, Monzani V. Henoch-Schönlein purpura with renal and gastrointestinal involvement in course of
COVID-19: a case report. Clin Exp Rheumatol. 2021 May 19;39(2):191–2. doi: 10.55563/clinexprheumatol/5epvob
44 Mousavi MS, Jafari M. COVID-19 in IGA vasculitis. Vol. 30, Iranian Journal of Pediatrics. 2020. doi: 10.5812/ijp.104424
45 Nakandakari Gomez MD, Marín Macedo H, Seminario Vilca R. IgA (Henoch Schönlein Purpura) Vasculitis in a Pediatric Patient with COVID-19 and
Strongyloidiasis. Revista de la Facultad de Medicina Humana. 2021 Jan 12;21(1):184–90. doi: 10.25176/RFMH.v21i1.3265
46 Falou S, Kahil G, Abou Merhi B, Dana R, Chokr I. Henoch Schonlein Purpura as Possible Sole Manifestation of Covid-19 in Children. Acta Scientific
Paediatrics. 2021;4(4). doi: 10.31080/aspe.2021.04.0377
47 Mayor-Ibarguren A, Feito-Rodriguez M, Quintana Castanedo L, Ruiz-Bravo E, Montero Vega D, Herranz-Pinto P. Cutaneous small vessel vasculitis
secondary to COVID-19 infection: a case report. Vol. 34, Journal of the European Academy of Dermatology and Venereology. 2020. doi: 10.1111/jdv.16670
48 Tahir A, Sohail Z, Nasim B, Parmar N v. Widespread cutaneous small vessel vasculitis secondary to COVID-19 infection. Vol. 59, International Journal of
Dermatology. 2020. doi: 10.1111/ijd.15106
49 Gómez MC, González-Cruz C, Ferrer B, Barberá MJ. Leucocytoclastic vasculitis in a patient with COVID-19 with positive SARS-CoV-2 PCR in skin biopsy.
BMJ Case Rep. 2020;13(10). doi: 10.1136/bcr-2020-238039
50 Capoferri G, Daikeler T, Mühleisen B, Trendelenburg M, Müller S. Cutaneous leukocytoclastic vasculitis secondary to COVID-19 infection leading to extensive
skin necrosis. Clin Dermatol. 2022. doi: 10.1016/j.clindermatol.2022.02.013
51 Alattar KO, Subhi FN, Saif Alshamsi AH, Eisa N, Shaikh NA, Mobushar JA, et al. COVID-19-associated leukocytoclastic vasculitis leading to gangrene and
amputation. IDCases. 2021;24. doi: 10.1016/j.idcr.2021.e01117
52 Dominguez-Santas M, Diaz-Guimaraens B, Garcia Abellas P, Moreno-Garcia del Real C, Burgos-Blasco P, Suarez-Valle A. Cutaneous small-vessel vasculitis
associated with novel 2019 coronavirus SARS-CoV-2 infection (COVID-19). Vol. 34, Journal of the European Academy of Dermatology and Venereology. 2020.
doi: 10.1111/jdv.16663
53 Iraji F, Galehdari H, Siadat AH, Bokaei Jazi S. Cutaneous leukocytoclastic vasculitis secondary to COVID-19 infection: A case report. Clin Case Rep.
2021;9(2). doi: 10.1002/ccr3.3596
54 Caputo V, Schroeder J, Rongioletti F. A generalized purpuric eruption with histopathologic features of leucocytoclastic vasculitis in a patient severely ill with
COVID-19. Journal of the European Academy of Dermatology and Venereology. 2020 Oct 2;34(10). doi: 10.1111/jdv.16737
55 Forni G, Mantovani A. COVID-19 vaccines: where we stand and challenges ahead. Cell Death Differ. 2021 Feb 21;28(2):626–39. doi: 10.1038/s41418-
020-00720-9
56 Gambichler T, Boms S, Susok L, Dickel H, Finis C, Abu Rached N, et al. Cutaneous findings following COVID-19 vaccination: review of world literature and
own experience. Vol. 36, Journal of the European Academy of Dermatology and Venereology. 2022. doi: 10.1111/jdv.17744
57 McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, et al. Cutaneous reactions reported after Moderna and Pfizer COVID-19
vaccination: A registry-based study of 414 cases. J Am Acad Dermatol. 2021;85(1). doi: 10.1016/j.jaad.2021.03.092
58 McMahon DE, Kovarik CL, Damsky W, Rosenbach M, Lipoff JB, Tyagi A, et al. Clinical and pathologic correlation of cutaneous COVID-19 vaccine reactions
including V-REPP: A registry-based study. J Am Acad Dermatol. 2022;86(1). doi: 10.1016/j.jaad.2021.09.002
59 Cohen SR, Prussick L, Kahn JS, Gao DX, Radfar A, Rosmarin D. Leukocytoclastic vasculitis flare following the COVID-19 vaccine. Vol. 60, International
Journal of Dermatology. 2021. doi: 10.1111/ijd.15623
60 Obeid M, Fenwick C, Pantaleo G. Reactivation of IgA vasculitis after COVID-19 vaccination. Vol. 3, The Lancet Rheumatology. 2021. doi: 10.1016/S2665-
9913(21)00211-3
61 Vassallo C, Boveri E, Brazzelli V, Rampino T, Bruno R, Bonometti A, et al. Cutaneous lymphocytic vasculitis after administration of COVID-19 mRNA vaccine.
Vol. 34, Dermatologic Therapy. 2021. doi: 10.1111/dth.15076
62 Bostan E, Gulseren D, Gokoz O. New-onset leukocytoclastic vasculitis after COVID-19 vaccine. Vol. 60, International Journal of Dermatology. 2021. doi:
10.1111/ijd.15777
63 Kharkar V, Vishwanath T, Mahajan S, Joshi R, Gole P. Asymmetrical cutaneous vasculitis following COVID-19 vaccination with unusual eosinophil
preponderance. Vol. 46, Clinical and Experimental Dermatology. 2021. doi: 10.1111/ced.14797
64 Sandhu S, Bhatnagar A, Kumar H, Dixit PK, Paliwal G, Suhag DK, et al. Leukocytoclastic vasculitis as a cutaneous manifestation of ChAdOx1 nCoV-19
corona virus vaccine (recombinant). Dermatol Ther. 2021;34(6). doi: 10.1111/dth.15141

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