DOI 10.53511/PHARMKAZ.2023.71.77.007
M.B. Abu1, A.А. Imamussenova1, L.K. Kudreyeva1, N.Zh. Zhumasheva1, A.M. Sarsenbayeva, K.M. Kedelbayeva2
1al-Farabi Kazakh National University, Almaty city, Republic of Kazakhstan
2Asfendiyarov Kazakh National Medical University, Almaty city, Republic of Kazakhstan
APPLICATION OF MOLYBDENUM-BASED BIOSENSORS
IN THE DIAGNOSIS OF DISEASES
Resume: Molybdenum transition metal compounds and nanoparticles have attracted much attention due to their unique physicochemical properties, multifunctional properties, and increased technological applications. This literature review reviewed the work of molybdenum compound biosensors based on research conducted over the past five years. Biosensors are analytical devices that combine a biological component and a physico-chemical component to produce a measured signal. In the course of the literature review, it was found that molybdenum-based biosensors were used to determine troponin-I, chronic myeloid leukemia, cyclic citrulline peptide, acetaminophen, Tau-381, dopamine, and epithelial cell adhesion molecules. It was found
that these sensitive biomarkers are very effective for diagnosis, predicting the rate of development of the disease and rehabilitation, evaluating pharmacological treatment — one of the main obstacles in the study of diseases such as acute myocardial infarction, arthritis, cancer and Alzheimer’s disease. As a result of the considered scientific works, such basic parameters of molybdenum-based biosensors as the detection limit relative to synthesis methods, electrochemical analysis methods, specificity, and the analysis under study were compared in tabular form. In general, the main purpose of this review is to conduct an analysis and a comprehensive review of the research work of molybdenum and its compounds used in the creation of a biosensor.
Keywords: biosensor; biomarker; troponin-I; molybdenum disulfide; molybdenum oxide; nanocomposite
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