STRUCTURAL AND FUNCTIONAL CHANGES IN ANIMAL ORGANS UNDER THE ACTION OF THE COMPONENT «SILYBUM MARIANUM (L.) Gaertn.» IN OBESITY

Received: 23.05.2024 Accepted: 29.04.2024 Published online: 29.06.2024
UDC: 615.244:582.998.1
DOI: 10.53511/pharmkaz.2024.42.69.021
Z.B.Yessimsiitova1, M.T.Tileshova1, A.S.Kozhamzharova2, G.Е.Yeltay1, G.A. Yestemirova1, Yerkinbek U.Y3,
S.E.Mombekov2
1al-Farabi Kazakh National University
2S.D.Asfendiyarov Kazakh National Medical University
3Abai Kazakh National Pedagogical University
Almaty, Kazakhstan
STRUCTURAL AND FUNCTIONAL CHANGES IN ANIMAL ORGANS UNDER THE ACTION OF THE COMPONENT
«SILYBUM MARIANUM (L.) Gaertn.» IN OBESITY
Resume: To date, despite the huge success in the creation of synthetic drugs, a large number of medicinal preparations
approved for use in scientific medicine include the active substances of higher plants. Medicinal plants are little studied and
are a source for studying their use as a remedy. The use of any drug without knowledge of all its pharmacological effects is
unacceptable. For modern medicine and pharmacy, the search for drugs with hepatoprotective activity still does not lose its
relevance. This article presents information regarding the efficacy and safety of the use of silymarin in patients with acute
toxic, including drug-induced, and chronic liver damage. In this regard, there is a need to study the currently available
information on the composition, pharmacokinetics, mechanisms of action of Silybum marianum (L.) Gaertn., as well as its
effectiveness in common diseases. The results of studies and systematic reviews of the use of silymarin in acute and chronic
liver damage of toxic and infectious pathology indicate the high efficiency and safety of this drug in case of poisoning by toxic
substances. At the same time, the question of the use of this plant as a dietary supplement remains not fully understood. At
present, the dynamics of regeneration processes under physiological conditions, with injuries and various pathologies of
tissues, has been quite fully studied and described. However, the regenerative processes at the cellular and subcellular level
in obesity remain insufficiently studied, which makes it possible to describe in more detail the essence of regenerative
processes, the ability to develop new methods for preserving the vital organ for the body, such as the liver and kidneys.
Key words: Silybum marianum (L.) Gaertn. spotted milk thistle, silymarin, liver, seeds, dietary supplements.

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