Received: 05.07.2023 /Accepted: 04.09.2023/ Published online: 29.12.2023
УДК 616.34-008-07-084
DOI 10.53511/PHARMKAZ.2024.25.65.015
N.M. SAMOILOVA-BEDYCH1, E.M. LARYUSHINA1, A.B. MARCHENKO1, A.K. SEISENBEKOVA1
1 NCJSC «Karaganda Medical University», Karaganda, Kazakhstan
THE ROLE OF THE INTESTINAL MICROBIOTA METABOLITE TMAO
IN THE PATHOGENESIS OF VARIOUS DISEASES
Resume: links in the pathogenesis of various diseases are a potential therapeutic target of pathogenetic
treatment. Modern trends and discoveries of metabolomics open a “window” for studying pathogenesis from
the point of view of the interaction of inter-organ axes associated with the intestinal microbiota. Every second
the intestinal microbiota through chemical reactions produces a huge number of substances, compounds,
enzymes which called «metabolites». Currently, one of the widely studied metabolites is trimethylaminetrimethylamine-N-oxide (TMAO). TMAO is a substance formed by the oxidation of trimethylamine, a product
of the breakdown of dietary free choline, phosphatidylcholine, and carnitine metabolism through the intestinal
microbiota. The presented review examines the effect of TMAO on the mechanisms of occurrence and
progression of diseases of the cardiovascular, gastrointestinal, endocrine, and nervous systems. Awareness of
its role in the pathogenesis of chronic non-communicable diseases provides new opportunities in approaches
to the treatment of patients.
Keywords: trimethylamine-N-oxide, microbiota, metabolite, pathogenesis, inflammatory bowel diseases,
metabolic-associated liver disease, atherosclerosis, chronic kidney disease, Alzheimer’s disease.
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