ANALYSIS OF ANTIBIOTIC CONSUMPTION IN THE NATIONAL CENTER OF CHILDREN’S REHABILITATION FOR 2019- 2020 IN THE CONDITIONS OF THE COVID-19 PANDEMIC

Received: 03.05.2024 Accepted: 13.06.2024 Published online: 29.06.2024
UDC 616.24-002-085.33:614.21.
DOI: 10.53511/pharmkaz.2024.16.40.003

L.G. Makalkina 1,2, M.Zh. Shakenov 2,A.N. Ihambaeva 1, Zh.A. Seikenova 2,
U.Sh. Abdrakhmanova 2, K.K. Kusainova 2, N.T. Aldiyarova 3
1 JSC «Astana Medical University», Astana, Republic of Kazakhstan
2 JSC “National center for children’s rehabilitation”, Astana, Republic of Kazakhstan 3RPA “Professional Association of Clinical
Pharmacologists and Pharmacists», Astana, Republic of Kazakhstan
ANALYSIS OF ANTIBIOTIC CONSUMPTION IN THE NATIONAL CENTER OF CHILDREN’S REHABILITATION FOR 2019-
2020 IN THE CONDITIONS OF THE COVID-19 PANDEMIC

Background. The COVID-19 pandemic has posed a major challenge for all humanity and health systems in all countries.
Excessive and unjustified use of antibiotics is one of the most important factors in the development of antibiotic resistance.
Objective of the study: to identify the dynamics of antibiotic consumption in a children’s rehabilitation center during the
COVID-19 pandemic for 2019-2020 and to identify factors affecting the incidence of infectious diseases and the consumption
of antibiotics.
Research methods: the calculation of antibiotic consumption was carried out according to the ATC / DDD methodology of
the WHO Collaborating Center for Drug Statistics Methodology using the WHO database [4] to assign the ATC index and DDD
values of drugs
Results: The total consumption of antibacterial agents for systemic use (group J01) showed a decrease in DBD in 2020
compared to 2019 by 40% and amounted to 39.29 DBD in 2019 and 28.04 DBD in 2020. When assessing dynamic
consumption antibiotics on arrival, we have identified a downward trend in antibiotic consumption after the introduction of
strict quarantine measures at the Center. That, combined with data for 2020 on a decrease in the number of patients who
were prescribed antibiotics and a decrease in the number of antibiotics per patient, showed the high effectiveness of
restrictive measures at the Center related to the COVID-19 pandemic.
Conclusions: the results of the study of antibiotic consumption for 2019-2020. according to the ATC / DDD methodology, it
revealed an overall decrease in consumption in 2020 compared to 2019 by 40%, which is a positive result of the strict
quarantine measures and an increase in the justification for prescribing antibiotics at the Center during the COVID-19
pandemic.
Key words: antibiotics, consumption, antibiotic resistance

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