ASSESSMENT OF COGNITIVE FUNCTION IN PATIENT WITH METABOLIC SYNDROME

Received: 25.01.2025 Accepted: 17.04.2025 Published online: 29.04.2025
УДК 616.43-056.52
DOI: 10.53511/pharmkaz.2025.2.2
ASSESSMENT OF COGNITIVE FUNCTION IN PATIENT WITH METABOLIC SYNDROME
Nemetova D.B. 1, Zhunisova M.B.
1
, Sadykova K.ZH. 1,
Nuskabayeva G.O. 1
, Tatykayeva U.B. 1, Dzhurabekova A.T. 2
1Khoja Akhmet Yassawi International Kazakh-Turkish University1 , Turkestan, Republic of Kazakhstan
2Samarkand State Medical University, Samarkand, Republic of Uzbekistan
Resume: The assessment of cognitive function at different ages is an important practical and scientific problem
that has not been sufficiently studied to date. Cognitive tests measure a number of important cognitive abilities
such as short-term and working memory, recognition and speed of information processing. Investigating the
relationship between metabolic syndrome and cognitive function may provide a better understanding of the
pathogenesis of cognitive impairment in adults.
Objective: To evaluate the association of cognitive function with clinical and metabolic parameters in
individuals with metabolic syndrome.
Methods: This study was conducted under AR grant funding 19676909 for 2023-2025. The study included 549
patients who underwent questionnaire, clinical and laboratory examinations, and cognitive function assessment.
Three tests were used to assess cognitive function: the Digit Symbol Substitution Test (DSST), the Stroop test,
and the Ray’s Auditory Verbal Learning Test (RAVLT). The data obtained during the study were subjected to
statistical processing using the trial version of the SPSS 25.0 program.
Results: 39.3% of the subjects had MS verified according to IDF (2005) criteria. The results show that in the
presence of individual components of MS there is a decrease in cognitive functions. Statistical analysis revealed a
negative relationship between the level of cognitive performance on the RAVLT (Ray’s Auditory Verbal Learning
Test) and the presence of MS components, in particular between systolic and diastolic blood pressure,
triglycerides, fasting blood glucose and waist circumference. The results show that these components of MS may
influence the state of cognitive functions.
Сonclusion: Metabolic syndrome is associated with cognitive decline, which explains the need for early
correction of metabolic syndrome. In middle-aged and elderly individuals, metabolic syndrome was closely
associated with impairment of short-term visual memory, psychomotor coordination and movement speed.
Keywords: metabolic syndrome, cognitive impairment, memory, neuropsychological tests

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