Received: 31.01.2023 / Accepted: 13.06.2023 / Published online: 30.06.2023
UDC: 615.322
DOI 10.53511/PHARMKAZ.2023.21.78.043

A.D. Karzhaubayeva1, K.K. Orynbasarova1, E.K. Orazbekov1, D.A. Konovalov 2
1JSC «South Kazakhstan Medical Academy», Shymkent, Kazakhstan
2«Pyatigorsk medical and Pharmaceutical Institute» — a branch of the federal state budgetary institution of Higher
Education «Volgograd State Medical University» of the Ministry of health of the Russian Federation, Pyatigorsk, Russia

SESQUITERPENE LACTONES OF PLANTS OF THE GENUS SAUSSUREA L.

Resume: The dependence of medicines on imports sharply worsens the situation with the supply of medicines
to the general population. Currently, many problems arise in order to ensure a systematic reduction in import
dependence on medicines and their substances for the treatment and Prevention of diseases in relevant
areas in the relevant industries. One of these relevant areas is the prevention and treatment of difficult-totreat diseases such as pneumonia, tuberculosis and viral. In connection with these circumstances, special
attention is paid to the search for new drugs against viruses, tumors and bacteria from natural domestic
raw materials. On the territory of the Republic of Kazakhstan, there is a significant increase in the import
of medicinal substances for the production of various types of medicines and BAS. The production of
domestic medicines is relevant in our country, replacing such plant raw materials. Aims: to identify and
use sesquiterpene lactones from medicinal plant raw materials as a promising medicinal source. Materials
and methods: Plant raw materials — Saussurea sordida and Saussurea alpina plants were used as objects.
The object of the study was the aboveground part collected in 2022 in the Turkestan region. To obtain the
extract, 96% percent ethyl alcohol was infused by maceration for 7 days. To isolate sesquiterpene lactones,
the method of maceration of ethyl alcohol with a percentage of 96% from plant raw materials was used.
Results and discussion: During the experiments, the presence of unsaturated compounds of sesquiterpene
nature was established: alcohols, lactones, azulenes, as well as higher alcohols and diterpene acids in the
herbs Saussurea Sordida Kar&Kir and Saussurea Alpina DC.
Keywords: medicinal plant raw materials, import dependence, sesquiterpene lactones, Pharmacognosy,
Saussurea L., traditional medicine.

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