Received: 20.11.2023 Accepted: 31.01.2024 Published online:29.02.2024
УДК: 616-002.2
DOI 10.53511/PHARMKAZ.2024.80.94.048
D.R. Tazhikov 1, V.B. Molotov- Luchancky 2, А. Malm 3
1 NPJSK “Medical University of Karaganda”, Karaganda, Kazakhstan
2 NPJSK “Medical University of Karaganda”, Karaganda, Kazakhstan
3″Medical University of Lublin”, Lublin, Poland
ELUCIDATING THE MECHANISMS OF NEUTROPHIL EXTRACELLULAR TRAPS
IN ACUTE RESPIRATORY DISTRESS SYNDROME PATHOGENESIS
Resume: This article critically examines the scientific literature related to the formation of neutrophil extracellular
traps and their impact on the pathogenesis and clinical course of acute respiratory distress syndrome (ARDS).
The available evidence indicates that the formation and accumulation of neutrophil extracellular traps in the
lung tissue are implicated in the development and progression of ARDS. Moreover, recent studies have shed
light on the potential mechanisms by which neutrophil extracellular traps contribute to impaired ventilationperfusion relationships in ARDS.
The findings presented in this review suggest that further research into the phenomenon of neutrophil
extracellular traps may lead to new insights into the pathophysiology of ARDS and inform the development
of novel therapeutic strategies. Specifically, targeting neutrophil extracellular traps may offer a promising
approach to attenuate the severity of ARDS and improve clinical outcomes. However, the complexity of the
underlying mechanisms and the heterogeneity of ARDS patients necessitate further investigation to identify
optimal therapeutic targets and treatment strategies.
Keywords: Neutrophil extracellular traps, oxidative stress, ARDS, acute lung injury.
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