Received: 22 May 2026
Accepted: 10 June 2026
Published online: 17 June 2026
UDC: 615.322:615.014.2:66.061.34
DOI: 10.53511/pharmkaz.2026.3.15
STUDY OF THE PHARMACEUTICAL AND TECHNOLOGICAL PARAMETERS OF THE
MEDICINAL PLANT RAW MATERIAL SESELI SESSILIFLORUM SCHRENK WITHIN
THE QUALITY BY DESIGN FRAMEWORK
Ibraeva M.B. ¹, Ridvanov Ch.I. ², Sakipova Z.B. ¹, Sermukhamedova O.V. ¹,³, Otarova F.A. ¹, Ibadullaeva G.S. ¹, Bekezhanova T.S. ¹
¹ S.D. Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
² “Abdi Ibrahim Global Pharm ” LLP, Vil. Mukhametzhan Tuimebaev, Ili district, Almaty region, Republic of Kazakhstan
³ “FitOleum” LLP, Esik, Republic of Kazakhstan
Introduction. This study aimed to investigate the pharmaceutical and technological parameters of the standardized medicinal plant material Seseli sessiliflorum Schrenk and assess their impact on mass transfer processes and extraction efficiency using selected elements of the Quality by Design approach.
Materials and Methods. The study involved medicinal plant material obtained from the aerial parts of Seseli sessiliflorum Schrenk. To confirm the compliance of raw materials with pharmacopoeial requirements, an assessment of quality indicators was carried out under the State Pharmacopoeia of the Republic of Kazakhstan. The pharmaceutical and technological properties of the raw materials were assessed based on the specific, volumetric and bulk density, porosity,
porousness and free volume of the layer. Extraction efficiency was assessed based on the extractant absorption coefficient and the content of extractive substances. The effects of raw material grinding and the concentration of the aqueousalcoholic solution were studied using response surface methodology and a central composite experimental design.
Results. It was established that changes in the degree of grinding are accompanied by changes in the structure of the medicinal plant material layer. A decrease in particle size leads to a decrease in interparticle space, changes in the porousness, porosity, and free volume of the layer, which affects the permeability of the layer for the extractant and the conditions of mass transfer during extraction. Second-order regression models were obtained, which describe the effect
of the degree of raw material grinding and the concentration of the aqueous-alcoholic solution on the absorption coefficient of the extractant and the content of extractive substances. The nonlinear nature of the studied dependencies with the formation of a region of rational process parameters was established. The maximum yield of extractive substances is achieved with 70% aqueous-alcoholic solution and raw material grinding of 3–5 mm.
Discussion. The influence of the degree of grinding of medicinal plant material and the concentration of the extractant is associated with changes in the structural characteristics of the raw material layer, including bulk density, volumetric density, porousness, porosity, and free volume of the layer, which determine the conditions of mass transfer and the extraction of extractive substances.
Conclusion. The obtained results allow us to consider the degree of grinding of the raw material and the concentration of the extractant as critical parameters of the extraction process and justify their use in the development of Seseli sessiliflorum Schrenk processing technology within the Quality by Design concept.
Keywords: Seseli sessiliflorum Schrenk; medicinal plant material; degree of grinding; pharmaceutical and technological parameters; extraction; response surface methodology; Quality by Design.
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