DEVELOPMENT OF TECHNOLOGY FOR OBTAINING EXTRACT OF ZERAVSHAN THYME (THYMUS SERAVSCHANICUS KLOKOV) AND ITS STANDARDIZATION

Received: 24.03.2023 / Accepted: 12.05.2023 / Published online: 30.06.2023
UDC 615.32:582.929
DOI 10.53511/PHARMKAZ.2023.80.82.038

B.S. Zhumakanova1, Z.B. Sakipova1, L.N. Ibragimova1 , A.A. Kessikova2, M.B. Ibrayeva1, S.V. Shvets1, A.A. Bakytkhanova1
1 S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
2 Abbott Kazakhstan LLP, Almaty, Kazakhstan

DEVELOPMENT OF TECHNOLOGY FOR OBTAINING EXTRACT OF ZERAVSHAN
THYME (THYMUS SERAVSCHANICUS KLOKOV) AND ITS STANDARDIZATION

Resume: S.D. Asfendiyarov KazNMU has developed an original technology for obtaining Zeravshan thyme
extract. A method for obtaining the extract using ultrasound with a regulated frequency is substantiated, which
makes it possible to get the maximum yield of biologically active substances from medicinal plant materials
with established pharmaceutical and technological parameters. The technology of three pilot batches was
transferred at the pharmaceutical company FitOleum LLP to GMP. Technological process validation was
successful. Technological regulations for production, quality specification «Seravshan thyme liquid extract»
and a draft regulatory document have been developed. Studies have begun on long-term stability testing of
the product. The developed method for obtaining the extract is patented (patent No. 6830 dated February
4, 2022).
Keywords: Seravschan thyme (Thymus seravschanicus), extract, technological process, raw material
standardization, technology transfer, stability.

REFERENCES
1 State Pharmacopoeia of the Republic of Kazakhstan. V. 3. — Almaty: Zhibek Zholy, 2014. — 872 p. European Pharmacopoeia, 11th Edition. Electronic resource:
https://pheur.edqm.eu/home
2 United States Pharmacopeia — the National Formulary 2023. Electronic resource: https://www.uspnf.com
3 Micucci M., Protti M., Aldini R., Frosini M., Corazza I., Marzetti C., Mattioli L.B., Tocci G., Chiarini A., Mercolini L., Budriesi R. Thymus vulgaris L. Essential
Oil Solid Formulation: Chemical Profile and Spasmolytic and Antimicrobial Effects. // Biomolecules, 2020. — № 10(6). – P. 860.
4 Ferreira L.E., Benincasa B.I., Fachin A.L., França S.C., Contini SSHT, Chagas ACS, Beleboni RO. Thymus vulgaris L. essential oil and its main component
thymol: Anthelmintic effects against Haemonchus contortus from sheep// Vet Parasitol, 2016. — № 228. – Р. 70-76.
5 Ciprandi G., Tosca M.A. Non-pharmacological remedies for post-viral acute cough// Monaldi Arch Chest Dis, 2021. — № 92(1). – Р. 32-38.
6 Patent of the Republic of Kazakhstan No. 6830 dated February 4, 2022. Method for obtaining an extract from thyme.
7 B.S. Zhumakanova, I. Korona-Głowniak, K. Skalicka-Wo´zniak, et al. Phytochemical Fingerprinting and In Vitro Antimicrobial and Antioxidant Activity of the
Aerial Parts of Thymus marschallianus Willd. and Thymus seravschanicus Klokov growing widely in Southern Kazakhstan // Molecules 2021. — № 26. – Р.
3193 (1-13).
8 Decision of the Council of the Eurasian Economic Commission dated January 26, 2018 No. 15 «On approval of the Rules for good practice in the cultivation,
collection, processing and storage of raw materials of plant origin»
9 State Pharmacopoeia of the Republic of Kazakhstan. V. 1. — Almaty: «Zhibek Zholy» Publishing House, 2008. – 592 p.

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