Received: 04.05.2026
Accepted: 29.05.2026
Published online: 17.06.2026
UDC: 615.322:615.281:582.736
DOI: 10.53511/pharmkaz.2026.3.10
STUDY OF THE PHYTOCHEMICAL COMPOSITION OF THE PLANT MATERIAL
OF TAMARIX RAMOSISSIMA LEDEB. AND THE ANTIMICROBIAL ACTIVITY OF ITS
EXTRACTS
Arailym Daulbayeva ¹, Gulnara Kadyrbayeva ¹, Kaldanay Kozhanova ¹, Pavel Mučaji ², Nurgali
Rakhymbayev ¹*, Nazerke Milisova ¹
¹ Asfendiyarov Kazakh National Medical University, Almaty, RK
² Faculty of Pharmacy, Comenius University Bratislava, Slovakia.
Introduction. The increasing resistance of microorganisms to antibiotics necessitates the search for new antimicrobial agents, with plant-derived biologically active compounds attracting particular interest. The aim of this study was to quantitatively determine the phytochemical composition of Tamarix ramosissima Ledeb. plant material and to evaluate the antimicrobial activity of extracts obtained under different extraction conditions.
Materials and Methods. The aerial parts of the plant were used in the study. The content of flavonoids, tannins, and hydroxycinnamic acids was determined using spectrophotometric methods. Extracts were obtained by ultrasonic maceration and percolation using 50% and 90% ethanol. Antimicrobial activity was assessed by the microdilution method against standard test strains, with determination of minimum inhibitory concentration (MIC) and minimum bactericidal
concentration (MBC).
Results. It was established that the plant material is rich in tannins (12.90 ± 0.15%), flavonoids (5.45 ± 0.08%), and hydroxycinnamic acids (1.94 ± 0.05%). The studied extracts exhibited antimicrobial activity against all tested microorganisms, with the highest sensitivity observed for Staphylococcus aureus strains (MSSA and MRSA) (MIC – 1.25 mg/mL). Lower activity was observed against Gram-negative bacteria.
Discussion. The obtained data showed that Tamarix ramosissima extracts demonstrated stronger activity against Grampositive bacteria, particularly Staphylococcus aureus strains. In addition, the extraction method and ethanol concentration were found to influence the antimicrobial activity of the obtained samples.
Conclusion. The obtained results indicate that Tamarix ramosissima plant material is a promising source of polyphenolic compounds, and its extracts may be considered as potential antimicrobial agents.
Keywords: T. ramosissima, phenolic compounds, flavonoids, tannins, antimicrobial activity.
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