Получена: 19.05.2023 / Принята: 15.05.2023 / Опубликована online: 30.06.2023
УДК 61:575:616.24
DOI 10.53511/PHARMKAZ.2023.32.87.009
Р.Б. Бекмагамбетова1, Ж.Б. Испаева1, М.О., Мустафина2, Н.Б. Джанабаева3,А.Ж. Семейгажина4
, Е.Ф. Ковзель5, Г.М. Тусупбекова6, М.А. Моренко7
1,2,3,4Казахский Национальный Медицинский Университет им. С.Д. Асфендиярова, Алматы, Республика Казахстан
5 Корпоративный Фонд “University Medical Center” Назарбаев Университета, Астана, Республика Казахстан
6Больница Медицинского центра Управления делами Президента Республики Казахстан,
Астана, Республика Казахстан
7НАО «Медицинский университет Астана» , Астана, Республика Казахстан
РОЛЬ ГЕНЕТИЧЕСКИХ ФАКТОРОВ В РАЗВИТИИ БРОНХИАЛЬНОЙ АСТМЫ:
АСТМА И ГЕНЕТИЧЕСКИЙ ПОЛИМОРФИЗМ
Резюме: Астма является наиболее распространенным хроническим заболеванием дыхательных
путей во всем мире. Бронхиальная астма (БА) – это гетерогенное заболевание, в основе развития которого лежат сложные взаимодействия между различными генами и факторами окружающей среды. По результатам полногеномных ассоциативных исследований (GWAS), главную и значимую роль в возникновении астмы и развитии играет генетическая предрасположенность. Целью
данной работы является проведение анализа имеющейся литературы, описывающее связь между полиморфными вариантами генов и астмой для понимания связи между возникновением и развитием БА и генетическими факторами.
Ключевые слова: бронхиальная астма, генетические факторы, полиморфизм генов, полногеномное ассоциативное исследование (GWAS), однонуклеотидный полиморфизм (SNP.
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