COMBINED THERAPY OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS AND GASTROPROTECTORS: MODERN APPROACHES TO ENHANCING THE SAFETY OF ANTI-INFLAMMATORY THERAPY

Received: 28.05.2026

Accepted: 09.10.2026

Published online: 30.10.2026

UDC: 615.212:615.243

DOI: 10.53511/pharmkaz.2026.5.3

Article type: Scientific review article

 

COMBINED THERAPY OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS AND GASTROPROTECTORS: MODERN APPROACHES TO ENHANCING THE SAFETY OF ANTI-INFLAMMATORY THERAPY

 

Assilbayeva J.A. ¹, Ahelova Sh. L. ¹, Kamanova A.A.¹*,                     

Ermukhamet E.F.¹, Makhanova Zh.A.¹, Askerbay  N.B.¹

¹ NJSC “Astana Medical University”, Astana, Republic of Kazakhstan

 

Introduction. The objective of the article is to analyze contemporary literature data regarding the possibilities of combined administration of NSAIDs with gastroprotectors and to evaluate their potential to enhancing the safety of anti-inflammatory therapy.

Material and methods. A review of domestic and international publications was cinducted using the PubMed, Scopus, Web of Science and Google Scholar databases. The study focused on the mechanisms of NSAID-induced adverse effects, the pharmacology of gastroprotectors and fixed-dosage combined forms.

Results. The analysis demonstrated that the use of gastroprotectors in fixed-dose combinations with NSAIDs, particularly with controlled release, reduces gastrointestinal complications while maintaining the efficacy of anti-inflammatory therapy.

Discussion. The article presents an analytical review of modern approaches to improving the safety of nonsteroidal anti-inflammatory drug therapy through the use gastroprotectors. It examines the mechanisms of nonsteroidal anti-inflammatory drug induced gastrotoxicity, the role of various groups of gastroprotectors, as well as strategies for their combined administration, including fixed-dosage forms with the sequential release of components. Data on the clinical and technological effectiveness of a combination nonsteroidal anti-inflammatory drugs and gastroprotectors are provided, demonstrating a reduction in the risk of gastrointestinal complications and an improvement in patient compliance.

Keywords: nonsteroidal anti-inflammatory drugs, anti-inflammatory therapy, gastrotoxicity, gastroprotectors, fixed-dose combined drug.

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